The Economic and Financial Implications of Supplying a Bioenergy Conversion Facility with Cellulosic Biomass Feedstocks

Comprehensive analyses are conducted of the holistic farm production-harvesting-transporting-pre-refinery storage supply chain paradigm which represents the totality of important issues affecting the conversion facility front-gate costs of delivered biomass feedstocks. Targeting the Middle Gulf Coast, Edna-Ganado, Texas area, mathematical programming in the form of a cost-minimization linear programming model(Sorghasaurus) is used to assess the financial and economic logistics costs for supplying a hypothetical 30-million gallon conversion facility with high-energy sorghum (HES) and switchgrass (SG) cellulosic biomass feedstock for a 12-month period on a sustainable basis. A corporate biomass feedstock farming entity business organization structure is assumed. Because SG acreage was constrained in the analysis, both HES and SG are in the optimal baseline solution, with the logistics supply chain costs (to the front gate of the conversion facility) totaling $53.60 million on 36,845 acres of HES and 37,225 acres of SG (total farm acreage is 187,760 acres, including HES rotation acres), i.e.,$723.67 per harvested acre, $1.7867 per gallon of biofuel produced not including any conversion costs, and$134.01 per dry ton of the requisite 400,000 tons of biomass feedstock. Several sensitivity scenario analyses were conducted, revealing a potential range in these estimates of $84.75-$261.52 per dry ton of biomass feedstock and $1.1300-$3.4870 per gallon of biofuel. These results are predicated on simultaneous consideration of capital and operating costs, trafficable days, timing of operations, machinery and labor constraints, and seasonal harvested biomass feedstock yield relationships. The enhanced accuracy of a comprehensive, detailed analysis as opposed to simplistic approach of extrapolating from crop enterprise budgets are demonstrated. It appears, with the current state of technology, it is uneconomical to produce cellulosic biomass feedstocks in the Middle Gulf Coast, Edna-Ganado, Texas area. That is, the costs estimated in this research for delivering biomass feedstocks to the frontgate of a cellulosic facility are much higher than the $35 per ton the Department of Energy suggests is needed. The several sensitivity scenarios evaluated in this thesis research provides insights in regards to needed degrees of advancements required to enhance the potential economic competitiveness of biomass feedstock logistics in this area

Economic Analysis of Cellulosic Feedstock for Bioenergy in the Texas Rio Grande Valley

Farm Management,

Detection of IMBHs with ground-based gravitational wave observatories: A biography of a binary of black holes, from birth to death

Even though the existence of intermediate-mass black holes (IMBHs, black holes with masses ranging between $10^{2-4}\,M_{\odot}$) has not yet been corroborated observationally, these objects are of high interest for astrophysics. Our understanding of the formation and evolution of supermassive black holes (SMBHs), as well as galaxy evolution modeling and cosmography would dramatically change if an IMBH were to be observed. From a point of view of traditional photon-based astronomy, {which relies on the monitoring of innermost stellar kinematics}, the {\em direct} detection of an IMBH seems to be rather far in the future. However, the prospect of the detection and characterization of an IMBH has good chances in lower-frequency gravitational-wave (GW) astrophysics using ground-based detectors such as LIGO, Virgo and the future Einstein Telescope (ET). We present an analysis of the signal of a system of a binary of IMBHs (BBH from now onwards) based on a waveform model obtained with numerical relativity simulations coupled with post-Newtonian calculations at the highest available order. IMBH binaries with total masses between $200-20000\,M_\odot$ would produce significant signal-to-noise ratios (SNRs) in advanced LIGO and Virgo and the ET. We have computed the expected event rate of IMBH binary coalescences for different configurations of the binary, finding interesting values that depend on the spin of the IMBHs. The prospects for IMBH detection and characterization with ground-based GW observatories would not only provide us with a robust test of general relativity, but would also corroborate the existence of these systems. Such detections should allow astrophysicists to probe the stellar environments of IMBHs and their formation processes.Comment: 30 pp. Accepted for publication ApJ. Event rates calculated from scratc

Isothiourea-catalyzed enantioselective α-alkylation of esters via 1,6-conjugate addition to para-quinone methides

Funding: We thank the ERC under the European Union's Seventh Framework Programme (FP7/2007-2013)/E.R.C. grant agreement n° 279850, AstraZeneca and EPSRC [EP/M506631/1 (J.N.A.)], Syngenta and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis [CRITICAT, EP/L016419/1 (W.C.H.)], and EPSRC [EP/M508214/1 (C.M.)] for funding. A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We thank the EPSRC UK National Mass Spectrometry Facility at Swansea University.The isothiourea-catalyzed enantioselective 1,6-conjugate addition of para-nitrophenyl esters to 2,6-disubstituted para-quinone methides is reported. para-Nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the para-nitrophenyl ester, is proposed to facilitate catalyst turnover in this transformation. A range of para-nitrophenyl ester products can be isolated, or derivatized in situ by addition of benzylamine to give amides, in up to 99% yield. Although low diastereocontrol is observed, the diastereoisomeric ester products are separable and formed with high enantiocontrol (up to 94:6 er).Publisher PDFPeer reviewe

A new technique for timing the double pulsar system

In 2004, McLaughlin et al. discovered a phenomenon in the radio emission of PSR J0737-3039B (B) that resembles drifting sub-pulses. The repeat rate of the sub-pulses is equal to the spin frequency of PSR J0737-3039A (A); this led to the suggestion that they are caused by incidence upon B's magnetosphere of electromagnetic radiation from A. Here we describe a geometrical model which predicts the delay of B's sub-pulses relative to A's radio pulses. We show that measuring these delays is equivalent to tracking A's rotation from the point of view of an hypothetical observer located near B. This has three main astrophysical applications: (a) to determine the sense of rotation of A relative to its orbital plane; (b) to estimate where in B's magnetosphere the radio sub-pulses are modulated and (c) to provide an independent estimate of the mass ratio of A and B. The latter might improve existing tests of gravitational theories using this system.Comment: Accepted for publication in MNRAS. 9 pages in emulated MNRAS format, 3 figure

Pulsar Timing and its Application for Navigation and Gravitational Wave Detection

Pulsars are natural cosmic clocks. On long timescales they rival the precision of terrestrial atomic clocks. Using a technique called pulsar timing, the exact measurement of pulse arrival times allows a number of applications, ranging from testing theories of gravity to detecting gravitational waves. Also an external reference system suitable for autonomous space navigation can be defined by pulsars, using them as natural navigation beacons, not unlike the use of GPS satellites for navigation on Earth. By comparing pulse arrival times measured on-board a spacecraft with predicted pulse arrivals at a reference location (e.g. the solar system barycenter), the spacecraft position can be determined autonomously and with high accuracy everywhere in the solar system and beyond. We describe the unique properties of pulsars that suggest that such a navigation system will certainly have its application in future astronautics. We also describe the on-going experiments to use the clock-like nature of pulsars to "construct" a galactic-sized gravitational wave detector for low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks, Springer Space Science Review

Trialling technologies to reduce hospital in‐patient falls: an agential realist analysis

This paper analyses the 'failure' of a patient safety intervention. Our study was part of an RCT of bed and bedside chair pressure sensors linked to radio pagers to prevent bedside falls in older people admitted to hospital. We use agential realism within science and technology studies to examine the fall and its prevention as a situated phenomenon of knowledge that is made and unmade through intra-actions between environment, culture, humans and technologies. We show that neither the intervention (the pressure sensor system), nor the outcome (fall prevention) could be disentangled from the broader sociomaterial context of the ward, the patients, the nurses and (especially) their work through the RCT. We argue that the RCT design, by virtue of its unacknowledged assumptions, played a part in creating the negative findings. The study also raises wider questions about the kind of subjectivities, agencies and power relations these entanglements might effect and (re)produce in the hospital ward

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is unclear whether such dysfunction is a cause or an effect of the underlying pathology, and whether it represents a viable therapeutic target. It is therefore imperative to utilise and optimise cellular models and experimental techniques appropriate to determine the contribution of mitochondrial dysfunction to neurodegenerative disease phenotypes. In this consensus article, we collate details on and discuss pitfalls of existing experimental approaches to assess mitochondrial function in in vitro cellular models of neurodegenerative diseases, including specific protocols for the measurement of oxygen consumption rate in primary neuron cultures, and single-neuron, time-lapse fluorescence imaging of the mitochondrial membrane potential and mitochondrial NAD(P)H. As part of the Cellular Bioenergetics of Neurodegenerative Diseases (CeBioND) consortium ( www.cebiond.org ), we are performing cross-disease analyses to identify common and distinct molecular mechanisms involved in mitochondrial bioenergetic dysfunction in cellular models of Alzheimer's, Parkinson's, and Huntington's diseases. Here we provide detailed guidelines and protocols as standardised across the five collaborating laboratories of the CeBioND consortium, with additional contributions from other experts in the field

Discovery of Three Wide-orbit Binary Pulsars: Implications for Binary Evolution and Equivalence Principles

We report the discovery of three binary millisecond pulsars during the Parkes Multibeam Pulsar Survey of the Galactic Plane. The objects are highly recycled and are in orbits of many tens of days about low-mass white-dwarf companions. The eccentricity of one object, PSR J1853+1303, is more than an order of magnitude lower than predicted by the theory of convective fluctuations during tidal circularization. We demonstrate that, under the assumption that the systems are randomly oriented, current theoretical models of the core-mass--orbital-period relation for the progenitors of these systems likely overestimate the white-dwarf masses, strengthening previous concerns about the match of these models to the data. The new objects allow us to update the limits on violation of relativistic equivalence principles to 95% confidence upper limits of 5.6 x 10^-3 for the Strong Equivalence Principle parameter Delta and 4.0 x 10^-20 for the Lorentz-invariance/momentum-conservation parameter alpha_3.Comment: 8 pages; accepted to ApJ. Small changes to parameters from including correct Parkes clock corrections; changes/corrections to Figures 1, 4 and 5; minor changes to text and references. The limit on Delta has increased from 0.0055 to 0.005